Factors predictive for chronic course of idiopathic thrombocytopenic purpura (ITP) in children

Idiopathic thrombocytopenic purpura (ITP) in children.

Idiopathic thrombocytopenic purpura in children remits spontaneously in the majority of cases but most children require treatment. Between 1995 and 2005, 265 children (0-15 years old) have been consecutively observed and treated: 28 children with high doses of methylprednisolone (HDMP) (15 mg/kgx4 days), 63 with HDMP (7.5 mg/kgx4 days), 37 with HD dexamethasone (DXM) pulses, 29 with low doses o...

Epidemiology of Idiopathic Thrombocytopenic Purpura in Children

Abstract Background Immune thrombocytopenic purpura (ITP) is a common autoimmune bleeding condition in children that is characterized by a decrease in the platelet count. The aims of this study were to define epidemiologic features of patients with primary ITP who were admitted to Mofid Children's Hospital, Tehran, Iran, in a 5-year period. Methods We retrospectively studied the records of ...

Predisposing and modulating genetic factors in idiopathic thrombocytopenic purpura (ITP)

About treatment of idiopathic thrombocytopenic purpura (ITP).

Their treatment results with megadose methylprednisolone (MDMP) support fairly closely our complete remission results, though theirs was a retrospective evaluation. In our prospective, comparative study, antiplatelet antibodies were also determined3. Their 80% complete remission rate (mistakenly written as 66% in the text) with MDMP administration was much better than other therapeutic approach...

Update on chronic immune thrombocytopenic purpura (ITP)

Platelet production and circulation Thrombopoietin (TPO), the major cytokine affecting all phases of platelet production, is produced primarily by the liver and binds to the c-Mpl receptor located on platelets, stem cells and megakaryocytes. Upon stimulation, pluripotential stem cells produce cells committed to megakaryocyte differentiation. These cells initially undergo mitosis followed eventu...